2016, Cilt 8, Sayı 2, Sayfa(lar) 001-006
The Paradigm of Autoimmunity: Is Vitamin D the New Player?
Gülbüz Sezgin1, Eşref M. Özer2, Oya Uygur Bayramiçli3, Feride Sinem Akgün4, Fehime Benli Aksungar5, Selim Nalbant1
1Departments of Internal Medicine, Maltepe University, Medical School, İstanbul
2Departments of Internal Medicine,Endocrinology, Maltepe University, Medical School, İstanbul
3Departments of Internal Medicine,Gastroenterology, Maltepe University, Medical School, İstanbul
4Departments of Internal Medicine, Emergency, Maltepe University, Medical School, İstanbul
5Biochemistry Department of Acıbadem University, Medical School, İstanbul
Keywords: nazolabiyal, V-Y ilerletme flebi, ortayüz defekti, ektropiyon

Aim: Vitamin D is necessary for the bone and mineral homeostasis and has also immune regulatory and anti-inflammatory functions. It has been hypothesized that there is a relation between vitamin D deficiency or insufficiency and autoimmune thyroiditis. We aim that to show any relationship between vitamin D deficiency and thyroid autoimmunity.

Material and Methods: This prospective study is performed between August 2010 and May 2011 at the Department of Internal Medicine, Endocrinology and Emergency Medicine of Maltepe University, School pof Medicine Hospital. The Ethics Committee of Maltepe University Medical Faculty approved the study.274 patients with Hashimoto’s thyroiditiswere evaluated prospectively for vitamin D, TSH, anti-thyroid peroxidase antibody (anti-TPO) and anti-thyroglobulin (anti-Tg).The correlation between vitamin D and autoimmune parameters is analyzed.

Results: According to vitamin D levels there is a statistically significant difference between anti- TPO levels (p=0.024; p<0.05). Anti-TPO levels of patients with a vitamin D level between 4-10 ng/ml are higher than that of the patients with a vitamin D level of 10.01-20 ng/ml and 20 ng/ml and over. Anti-Tg and TSH levels are not statistically significantly different according to vitamin D levels (p=0.550; p=0.554; p>0.05). There is also no difference in TSH levels according to vitamin D subgroups (p=0.177; p>0.05).

Conclusion: In patients with Hashimoto’s thyroiditis there is a positive correlation between vitamin D level and anti-TPO but not anti-Tg.