2017, Cilt 9, Sayı 3, Sayfa(lar) 049-052
Allergic reaction against methylene blue in both of the breasts after sentinel lymph node biopsy
Kağan Gökçe1, Mehmet Aslan1, Serkan Akbulut2
1İstanbul Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, Genel Cerrahi Kliniği, İstanbul, Türkiye
2Adana Şehir Hastanesi, Genel Cerrahi Kliniği, Adana, Türkiye
Keywords: Allergic Reaction, Erythema, Methylene Blue, Sentinel Lymph Node

The sentinel lymph node biopsy (SLNB) is the gold standard in staging of breast cancer. Blue dye, lymphoscintigraphy and sentimag are three main methods described for SLNB. Blue dye use for SLNB is more cost-effective when compared to other two methods. Patent blue, isosulfan blue and methylene blue are vital dyes, which are used to identify the sentinel lymph node (SLN). Methylene blue is easily available and less expensive than other dyes. Injection of methylene blue into the parenchyma to identify SLN is safe during breast cancer operation, although in some cases allergic reactions have been reported. In this case a 83 years old female patient with right side breast cancer has presented. The patient was treated with partial mastectomy and SLNB. Methylene blue dye was used for SLNB. After operation erythema has seen in both of the breasts. The aim of the case report is to present this rare allergic reaction against methylene blue dye.