2018, Cilt 10, Sayı 2, Sayfa(lar) 058-061
Anestheshetic management in a patient with MELAS syndrome receiving the diagnosis of toxic megacolon
Tülay Örki1, Lale Kurul Özcan2, Deniz Avan1
1Kartal Koşuyolu Y.İ. E.A.Hastanesi, Anesteziyoloji ve Reanimasyon Kliniği, İstanbul, Türkiye
2Özel Göztepe Hastanesi, Yoğun Bakım Ünitesi, İstanbul, Türkiye
Keywords: MELAS syndrome, toxic megacolon, anesthetic management

MELAS syndrome is a progressive, neurodegenerative genetic disorder characterized by point mutations in the mitochondrial DNA, mitochondrial myopathy, lactic acidosis, encephalopathy, and stroke-like episodes. The syndrome has high morbidity and mortality, affecting all the organs, especially the brain, cardiovascular, gastrointestinal and neuromuscular systems. Due to metabolic acidosis, tendency to hypothermia and to malign hyperthermia, increased resistance to muscle relaxants as well as prolonged effects, the method for anesthetic management, monitorization, medication and fluid regimes are of crucial significance for anesthesiologists in these patients. In this article, we present anesthetic management performed on a patient with MELAS syndrome who had received the diagnosis of toxic megacolon and underwent emergency hemicolectomy.